A coronavirus drive-through testing site at the Theodore Roosevelt Nature Center on March 17, 2020, at Jones Beach State Park, New York. It was the first drive-through coronavirus testing site on Long Island. (Al Bello/Getty Images)
WASHINGTON — Scientists debated the origins of COVID-19 on Tuesday, trading barbs over whether the bulk of evidence available points to a natural spillover event from a wild animal or a virus designed in a lab and then let loose through an inadvertent leak.
The hearing in front of the U.S. Senate Homeland Security and Governmental Affairs Committee was part of ongoing efforts in Congress to apply the lessons learned during the pandemic to prevent or blunt the next outbreak.
Gregory Koblentz, associate professor and director of the Biodefense Graduate Program at George Mason University in Virginia, said during the two-hour hearing that debate continues in the scientific community about the origins.
“The possibility that SARS-CoV-2 was deliberately developed as a biological weapon has been unanimously rejected by all U.S. intelligence agencies,” Koblentz testified. “While the intelligence community is divided on the origin of the pandemic, most of the agencies have determined that the virus was not genetically engineered.”
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Residents in Wuhan, China, were first diagnosed with “an atypical pneumonia-like illness” in December 2019, according to a COVID-19 timeline from the Centers for Disease Control and Prevention.
Initial cases all appeared linked to the Huanan Seafood Wholesale Market at the time, though there has since been much speculation about the types of research taking place at the Wuhan Institute of Virology.
Koblentz said he believes the available evidence points to a spillover event from an animal, though he added a “research-related accident can’t be ruled out at this time.”
The lack of transparency and data from the Chinese government has significantly hindered scientists’ efforts to unify around the origin of COVID-19, he said.
Scientists battle over lab vs. spillover
Richard Ebright, board of governors professor of chemistry and chemical biology and laboratory director at the Waksman Institute of Microbiology at Rutgers University in New Jersey, testified he believes a “large preponderance of evidence indicates SARS-CoV-2, the virus that causes COVID-19, entered humans through a research incident.”
Ebright also leveled criticism at fellow panelist Robert Garry, who, along with a handful of co-authors, published an opinion article in the journal nature medicine in March 2020, titled “The proximal origin of SARS-CoV-2.”
In the commentary, Garry and the other scientists wrote, “we do not believe that any type of laboratory-based scenario is plausible.”
Ebright said during Tuesday’s hearing that the opinion article represented “scientific misconduct up to and including fraud,” a characterization that Garry rejected during the hearing.
“The authors were stating their opinion, but that opinion was not well-founded,” Ebright said. “In March of 2020, there was no basis to state that as a conclusion, as opposed to simply being a hypothesis.”
Garry, professor and associate dean of the School of Medicine at Tulane University in Louisiana, argued on behalf of the spillover event during the hearing, testifying that the virus likely didn’t move directly from a bat to humans, but went to an unidentified intermediary animal.
“The bat coronaviruses are viruses that are spread by the gastrointestinal route,” Garry said. “For a virus like this to become a respiratory virus — it’s just going to require too many mutations, too many changes for a bat virus to spill directly over to a human being. That could only really happen in nature with replication through an intermediate animal.”
Garry also defended gain-of-function research during the hearing, arguing that it has had some beneficial impact, though he noted that it does need “appropriate safeguards and restrictions.”
Lawmakers and pundits have used several, often evolving, definitions for gain-of-function research in the wake of the COVID-19 pandemic. The American Society for Microbiology defines it as techniques “used in research to alter the function of an organism in such a way that it is able to do more than it used to do.”
When research is “responsibly performed” on highly transmissible and pathogenic viruses, it can lead to advances in public health and national security, Garry testified.
“Without gain-of-function research, we’d have no Tamiflu. Without gain-of-function research, we wouldn’t have a vaccine to prevent cancer caused by infection by the human papilloma virus,” Garry said. “And without gain-of-function research, we won’t be able to identify how novel viruses infect us. And if we don’t know how they infect us, we cannot develop appropriate treatments and cures for the next potential pandemic creating virus.”
Oversight of funding, research
New Hampshire Democratic Sen. Maggie Hassan raised several questions about whether there’s enough oversight of how the United States spends research dollars as well as what mechanisms are in place to monitor how private entities conduct certain types of research.
“While their research has the potential to cure diseases and boost our economy, unless they accept federal funding, there is very little federal oversight to ensure that private labs are engaged in safe and ethical research,” she said.
Koblentz from George Mason University said there is much less oversight of biosafety and biosecurity for private research facilities that don’t receive federal funding.
“In order to expand the scope of oversight to all privately funded research, (it) would require legislative action,” Koblentz said.
Congress, he said, should establish a national bio-risk management agency that would have authority over biosafety and biosecurity “regardless of the source of funding.”
“At the end of the day, it shouldn’t matter where the funding comes from in terms of making sure this research is being done safely, securely and responsibly,” Koblentz said.
Kentucky Republican Sen. Rand Paul, ranking member on the committee, said the panel will hold an upcoming hearing specifically on gain-of-function research, including what steps Congress should take to ensure it doesn’t put the public at risk.
The next pandemic
Committee Chairman Gary Peters, a Michigan Democrat, said during the hearing that lawmakers “must learn from the challenges faced during this pandemic to ensure we can better protect Americans from future potential biological incidents.”
“Our government needs the flexibility to determine the origins of naturally occurring outbreaks, as well as potential outbreaks that could arise from mistakes or malicious intent,” Peters said.
Utah Republican Sen. Mitt Romney, after listening to some of the debate, expressed exasperation that so much attention is going toward what caused the last pandemic and not on how to prepare for the next one.
“Given the fact that it could have been either, we know what action we ought to take to protect from either,” Romney said. “And so why there’s so much passion around that makes me think it’s more political than scientific, but maybe I’m wrong.”
The United States, he said, shouldn’t be funding gain-of-function research and should “insist” that anyone who receives federal funding follow the standards of the International Organization for Standardization.
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